Thursday, April 25, 2013

Uncharted Blues Dept.: I Think This "Fixes" The MK-5172 Model -- Do Let Me Know. . .

See here, for some great chemists' assists -- and more of them, here (left by chemist commenters, at the back-up site, actually) -- on this topic, by way of background.

I think this does it -- but before I start replicating it, and using it in more story graphics, do weigh in, and tell me whether I've got it down right.

We have traveled beyond the safe harbors of the chemistry I know (or once knew), out into the vast, deep and uncharted azure blues of the oceans I've never sailed, now. That is, I've hit the wall -- on what little training in chemistry I had, as a lad.

So I now throw myself onto the mercy of the wise and benevolent professors, here assembled. Click at right to enlarge -- then tell me if it works.


Anonymous said...

Close, but not quite. The t-butyl group (the residue that looks like a cross) should be pointed down (i.e. into the page) to depict the correct stereochemistry. Also the vinyl group (-CH=CH2) off of the cyclopropyl ring should be cis to the sulfonamide group (you have drawn it as trans right now). Finally, in your stick drawing, the double bond should be between the carbon and the oxygen of the acyl sulfonamide and a single bond should be between the carbon and the nitrogen (you currently have a single bond between the carbon and oxygen and a double bond between the carbon and nitrogen).

Condor said...


I may end up taking just a little artistic license, when I repost the changed graphic. . . afterall, my purpose is not to manufacture the drug -- but to give a visual sense of it.

Thanks for all your wisdom and guidance, here -- and do stop back!