. . . .Here are my thoughts, and this seems relevant to Merck because they have a niacin drug in development.
In ARBITER 6-HALTS, niacin was superior to ezetimibe, when added to a statin, but it was unclear if ezetimibe is harmful, niacin is beneficial, or both. The results in AIM-HIGH, showing no benefit for niacin when added to a statin, make it more likely that the ARBITER 6-HALTS results mean that ezetimibe is harmful. . . .
I've seen other comments -- to suggest that Merck's tredaptive candidate may have a tougher road, now due to the Abbott announcement, this week -- but this is the first suggesting that Zetia® may ultimately be found to be affirmatively harmful.
We'll keep an eye on this.