Thursday, August 5, 2010

H/T Pharmalot: Merck's Proteomics Efforts -- BioITWorld

That fine gent, Ed Silverman, over at Pharmalot, alerts us to a story in BioITWorld, overnight -- do go read it all:

. . . .Researchers looked at 375 phosphorylation sites in the PI3-kinase pathway, and used three pathway inhibitors to identify drug-regulated phosphorylation events. Each of the three test drugs modulated a specific array of phosphopeptides, with some overlap. The hope, Hendrickson said, is that "by measuring biomarkers in tumor tissue before treatment, clinicians can directly test whether the cancer-causing mechanisms that a drug specifically targets are active in the patient’s tumor. . . ."

"Merck may seek to explore the full impact that this technology could have on our oncology pipeline of kinase inhibitors as well as our broader pipeline but it is still early days. . . ."

Most tumor characterization looks at genetic mutations causing cancer, but this approach provides only vague information about the molecular causes of tumor growth. Phosphoproteomics, however, reveals activated pathways in tumors, providing a more precise way to directly tell whether or not a certain drug will work for a patient. . . .

This, too, may come up on the BMO webcast to be delivered by Merck, in about an hour.


Anonymous said...

This is likely part of the previously announced layoffs but, it is at least posted for those interested.

Thanks Fred!

condor said...

Thanks for the heads up!

Just made yours a new post, here.


Anonymous said...

There are down sides to looking at the phosphorylation status of specific protein(s) to identify the activated pathways in the cancer... a major downside is that this is a 'dynamic' process... the snapshot of the tumor may not be stable, i.e. may change over time. It may be argued that somatic or germline mutations may be more 'stable'. A combination of all techniques available, although not efficient, will be the most informative for treatment.


canadian52 said...

Thanks for this. Can I share an excellent workshop facilitated by Dr. Ning Liu of Bio-Rad Laboratories that covers the details involved in 2D Gel electrophoresis including sample prep, running the gel and data analysis with a major focus on sample preparation. May be of interest.