Even if one tried, it would be difficult to make up a stranger story, stranger than the true story: the one that leads to this moment, in the "Further Asenapine Chronicles" -- now awaiting word from the FDA's PDUC meeting -- on Saphris/Asenapine, this evening [click thumbnails of pages, at right to enlarge]:
. . . .Take a look beginning at page 963 of the asenapine PDAC background package. The OCP reviewer begins to lay out structure activity relationships and why similar toxicities may be occurring with a wide variety of drugs ( i.e. the 3D structures may allow binding to the same binding sites.)
On page 967 he looks at the antihelminic mectins (Merck and SP animal drugs) and you can see he's postulating that the effects on bones seen with the animals studies of the various antipsychotics described elsewhere in the reviews may be related to these drugs causing bone chips in the knees of race horses.
Since these drugs are also given to farmed salmon(!) this raises the possibility of these being toxins in the human food chain. [Ed. Note: Click at right -- to enlarge the image of Page 969 -- Agent Orange; Dioxin. . . .]
There's actually an article related to this in the December 2008 issue of of Drug Safety as well as another article in that issue by Dr. Zornberg the FDA team leader on asenapine that basically outlines all the OCP reviewer's concerns.
July 30, 2009 12:36 PM. . . .
Wow. Keep it comin'. . . we still are awaiting word from the Hilton on Colesville Road, in Silver Springs, Maryland.