Monday, September 12, 2022

Another Nice (If Still Early) Study Result For A Keytruda® Combo... This Time, In A Subset Of Urothelial Cancers...


Not Earth shaking, but good news, just the same -- to be sure.

And with each positive top-line study result, the odds shorten -- that Merck will ultimately be willing to pay perhaps $38 billion in cash to acquire Seagen, lock, stock and barrel. We shall see, but here is the latest, on Monday morning:

. . .Astellas Pharma, Seagen and Merck said Padcev and Keytruda showed a 64.5% confirmed objective response rate (ORR) in patients with a specified type of urothelial cancer.

The companies presented data from a phase 1b/2 trial, dubbed EV-103 (also known as KEYNOTE-869), Cohort K evaluating Padcev (enfortumab vedotin-ejfv) in combination with Merck's Keytruda (pembrolizumab) and Padcev alone as first-line treatment in patients with unresectable locally advanced or metastatic urothelial cancer (la/mUC) who are ineligible to receive cisplatin-based chemotherapy, at the 2022 European Society for Medical Oncology (ESMO) Congress. . . .


Now you know. . . as the weather here now cools, we keep reflecting on moments of each passing day, in this month -- all of exactly a decade ago, now. . . grinning ear to ear. Some things change -- but some. . . never do.

नमस्ते

4 comments:

  1. Article on CNN says Trump objecting to DOJ's proposed special masters but had declined to give reasons. Claims that if requested reasons can be provided. Sounds like another delaying tactic to me.

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  2. Thanks Anon. Yep -- it is a specious filing, top to bottom.

    Since this is going to run faster and more furious in the next few weeks -- well beyond my bandwidth, let me point you to the single most authoritative review of all things warrant at Mar-A-Lago related, by someone who is clearly an expert in top secret government documents. Read hers every day, to know what the best and brightest think:

    https://www.emptywheel.net/2022/09/12/donald-trump-agrees-he-is-living-by-barack-obamas-rules/

    Now -- as to this notion of "I'll tell you later if you ask" -- in response to a federal judge's order that ALREADY asked, explicitly in writing last week. . . one would expect a very stern dressing down, from almost any other federal judge.

    But given that she's in the tank for Tangerine. . . I expect she'll just cha-cha along. This would be met with scorching and justifiable anger, as to the rights and privileges of sitting federal judges to order litigants seeking redress from the court, to obey court rulings. But Tangerine writes that "HE" has decided to read her order in a very cramped fashion, thus:

    "...Plaintiff [Donald Trump] has construed that Order in a limited fashion....

    Plaintiff also submits it is more respectful to the candidates from either party to withhold the bases for opposition from a public, and likely to be widely circulated, pleading. Therefore, Plaintiff asks this Court for permission to specifically express our objections to the Government’s nominees only at such time that the Court specifies a desire to obtain and consider that information...."
    [Ed. Note: here Trump tells Judge Cannon, in effect, that she is being disrespectful to the special master candidates by airing this in public -- but that is what the courts do -- they serve "we, the people" not Trump. Moreover, this is how it is done everyday -- in the Florida federal courts, in public view -- see the appointment of Barbara Jones in the Estate of Kleiman v. Craig Wright case (a potentially $37 billion lawsuit, with a jury verdict of well over $100 million), here.]

    "...Such information could then be provided in camera or pursuant to whatever procedure the Court deems most efficient and appropriate. Consistent with that approach, Plaintiff is willing to provide our specific rationale for supporting our nominees if and when the Court so orders...."


    Day by day, Cannon here absolutely confirms the judgment of the American Bar Association -- in rating her "not qualified" for the federal bench.

    Y I K E S. . . .

    I'll likely post something later tonight on all of this.

    Thanks Anon.!

    ReplyDelete
  3. Not really sure what this is in reference to… but it will remain.

    Cheers.

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